Alun-Wyn Jones will start in the second row alongside Luke Charteris, with Toby Faletau, Justin Tipuric and Dan Lydiate rekindling their back row partnership.
Up front, Paul James will win his 49th cap alongside Adam Jones and hooker Richard Hibbard.
In the back division, Rhys Priestland has been preferred at fly half to last season's first choice Dan Biggar, who hasn't even made the substitutes bench.
Jamie Roberts and Scott Williams will join up in midfield while the tried and tested back three of Halfpenny, Cuthbert and North complete Wales' starting fifteen.
Warburton will be joined on the bench by Scarlets forward pair Ken Owens and Rhodri Jones, as well as Ryan Bevington and Andrew Coombs.
Ospreys scrum half Rhys Webb deputises at half-back, alongside James Hook and Scarlets back Liam Williams.
WALES SQUAD TO PLAY ITALY:
Leigh Halfpenny (Cardiff Blues), Alex Cuthbert (Cardiff Blues), Scott Williams (Scarlets), Jamie Roberts (Racing Metro), George North (Northampton Saints), Rhys Priestland (Scarlets), Mike Phillips (Racing Metro), Paul James (Bath Rugby), Richard Hibbard (Ospreys), Adam Jones (Ospreys), Luke Charteris (Perpignan), Alun-Wyn Jones (CAPT – Ospreys), Dan Lydiate (Racing Metro), Justin Tipuric (Ospreys), Taulupe Faletau (Newport Gwent Dragons).
Replacements: Ken Owens (Scarlets), Ryan Bevington (Ospreys), Rhodri Jones (Scarlets), Andrew Coombs (Newport Gwent Dragons), Sam Warburton (Cardiff Blues), Rhys Webb (Ospreys), James Hook (Perpignan), Liam Williams (Scarlets).