Last year the Wales Air Ambulance notched up sixteen hundred missions and helped save hundreds of lives.
ITV Cymru Wales has had exclusive access to the action, and has been on board the three helicopters in Wales.
With the paramedics wearing special body cameras, you can see what they see as the crews respond to medical emergencies.
The six-part series starts on Friday 5 September at 8pm.
Our cameras follow the crews as they respond to emergency calls from their bases at Welshpool, Caernarfon and Swansea.
Watch a preview of the new series below
ITV News anchor Andrea Byrne meets the people – in the air and on the ground - who work for the Wales Air Ambulance service and the patients whose lives depend on it.