Midfielder David Edwards expects Ben Woodburn will "thrive" in Gareth Bale's absence after calling for Wales' players to show extra responsibility in Georgia.
Wales flew to Tbilisi on Wednesday afternoon for their penultimate 2018 World Cup qualifier against Georgia without talisman Bale.
The Real Madrid star has been ruled out of the final two games - Wales also host the Republic of Ireland in Cardiff on Monday - with a calf strain that could keep him sidelined for several weeks.
Bale's injury has come at a critical time with second-placed Wales four points behind Group D leaders Serbia and one above the Republic.
Wales must win their final two games to guarantee themselves at least a place in next month's play-offs.
Their record without Bale does not make pretty reading - Wales have not won any of their last 10 games when the 28-year-old has been absent - but midfielder Edwards believes the leaders in the squad have to stand up.
Liverpool striker Woodburn, who turns 18 later this month, scored the winner against Austria last month, less than five minutes after coming on as a second-half substitute.
Three days later, Woodburn set up the opening goal in the 2-0 win in Moldova after being introduced on the hour mark.
Arsenal midfielder Ramsey will win his 50th cap in Tbilisi and could be utilised in a more advanced position in Bale's absence.
But boss Chris Coleman is not short of attacking options with Woodburn, Sam Vokes, Hal Robson-Kanu and David Brooks all available.
Barnsley's Ryan Hedges has also been called up to cover the injured Marley Watkins.