Jamie Roberts could be in the frame for a Test match recall when Wales tackle world champions New Zealand on Saturday.
The 31-year-old Harlequins centre, who has won 93 caps, was a surprise omission from Wales' original autumn squad.
With Gloucester's Owen Williams appearing nailed-on to wear the number 12 shirt at the weekend, it might be that Roberts wins head coach Warren Gatland's vote alongside him.
Wales have lost a second British and Irish Lion through injury, with Saracens back Liam Williams being released from the squad due to an abdominal injury suffered during last Saturday's 13-6 victory over Georgia.
Both Williams and Davies were star performers of the Lions' New Zealand tour earlier this year.
And in another injury setback, Cardiff Blues wing Alex Cuthbert is sidelined by a calf muscle problem.
"It doesn't come easy for us, does it?" Edwards added. "As we always say, we just get on with it, and it's the next guy up on the roster."
With Williams out, it is likely that Leigh Halfpenny will be joined in the back-three by wings Hallam Amos and Steff Evans.
Wales have not beaten New Zealand since 1953, losing 29 successive Tests against them, and Edwards knows another major test awaits, especially defensively opposite an All Blacks back division containing the likes of Beauden Barrett and Sonny Bill Williams.