Warren Gatland acknowledged the qualities of a "clinical" Ireland team after they moved in sight of their third Six Nations title under head coach Joe Schmidt.
Ireland will head into next month's final two fixture rounds on a high after opening up a healthy five-point lead over reigning champions England.
A 37-27 bonus point victory against Gatland's Wales - coupled with England's Calcutta Cup defeat to Scotland - means Ireland are firmly on course to reclaim a trophy they last won in 2015.
Wales made 225 tackles in the game as Ireland dominated possession and territory, while the visitors' penalty count proved higher than during either of their opening two matches against Scotland and England.
Wales close their Six Nations campaign in Cardiff through appointments with Italy and France.
And Gatland is set to make changes for the Azzurri's visit, with wing George North, hooker Elliot Dee and number eight Taulupe Faletau among those looking likely to be in contention for starting places.
Powerhouse North made his presence felt off the bench for a second successive game.