Defender Federico Fernandez is in line to make his first Premier League start against Southampton this afternoon after Jordi Amat was ruled out with injury.
The Spanish centre-half suffered knee ligament damage in last week's defeat to Chelsea and is expected to be out for around six weeks.
The Argentine international stands by to fill in the position alongside captain Ashley Williams.
Elsewhere striker Wilfried Bony could replace Bafetimbi Gomis up front in today's game at the Liberty.
The Ivorian was dropped to the bench at Stamford Bridge following his late return from African Nations Cup duty.
Danny Gabbidon and Scott Young take charge of first team affairs this afternoon following the departure of Ole Gunnar Solskjaer yesterday.
The Bluebirds find themselves in 17th place in the Championship, with a record of one league win in five following their midweek defeat to Middlesbrough.
Cardiff travel to 7th placed Derby County today, who will be boosted after a hard-fought 3-2 win away against Blackburn on Wednesday.
Elsewhere in the Football League Newport will be looking to end Shrewbury's 100% home record in League 2 - they travel to the Greenhous Meadow on the back of a goalless draw with Tranmere on Tuesday.
Police have seized around five kilogrammes of what they suspect to be cocaine from a property in Tonypandy.
The drugs, which could be worth as much as £350,000 – were discovered in a box concealed in plastic packaging.
Drug processing equipment was also recovered from the house.
A 33 year-old man has been arrested on suspicion of drugs offences and is currently in police custody. The investigation is ongoing.
Anyone with information is asked to contact 101 or call Crimestoppers anonymously on 0800555 111.
The chief executive of Wales' ambulance service is to step down due to ill health, it has been announced.
Officials said Elwyn Price-Morris had been suffering with serious health problems over the past six months.
However, a spokeswoman said Mr Price-Morris had now "accepted medical advice" in deciding to take "time away from the workplace".
She added: "Elwyn has held discussions with the Chairman of the Trust and they have reached a mutual decision that in his own interest and the interests of the service, he will not be returning to the chief executive's post once his health issues are resolved."
Seventy years ago today an RAF Liberator bomber crashed in the Preseli hills, killing 6 of the 9 men on board.
For the last 30 years the event has been commemorated every year - and today the nephew of one of the airmen who died made the trek too . Our West Wales Correspondent Kevin Ashford was there, and sent this report:
The First Minister, Carwyn Jones, told ITV News that today is a 'good day' for Wales.
Speaking to our presenter, Jonathan Hill, the First Minister said: "If Scotland had voted 'yes' the next two years would all be about Scotland, and no focus at all on Wales or Northern Ireland."
Calls have begun among MPs for Westminster to devolve more powers across the rest of the United Kingdom following Scotland's vote to remain within the union.
But what does this mean for Wales? And what kind of powers could Wales potentially get? Our reporter, Megan Boot, has been taking a look...
A memorial has been held in the Preseli hills in Pembrokeshire to remember the 6 men who died when their RAF Liberator bomber crashed there in 1944.
Members of the Pembrokeshire Aviation Group, which includes relatives of a crew member involved in the crash, marked the 70th anniversary of the crash with a walk up to the crash site near Carn Bica.