With their Six Nations title hopes now all but gone, Wales head coach Warren Gatland admits the countdown to next year's World Cup is on.
We take a look back through the archive to find the most iconic moments from Six Nations clashes between Wales and England.
Wales face England as they bid to keep their Six Nations title hopes alive. But can they overcome the resurgent red rose brigade?
Cardiff City have secured a win against fellow Premier League relegation contenders, Fulam.
Two goals from Stephen Caulker helped the Bluebirds to a 3 - 1 victory at the Cardiff City Stadium.
Forwards coach Robin McBryde insists Wales will embrace tomorrow's match at Twickenham, after declaring, 'the hottest fires forge the toughest steel'.
England, presumably still reeling from their 30-3 defeat in Cardiff last year, have been revealed as the favourites to win against Wales, in the all-important 6 Nations showdown.
McBryde says he fears the backlash of beating Stuart Lancaster's men at the Millennium Stadium, but knows the psychological impact victory would have, ahead of their meeting in the group stage of the 2015 World Cup.
"England are a better team than last year and any bad experience, as long as you learn from it, can be turned into a big positive. That result in Cardiff could work against us.
We have to embrace this occasion because it won't get any easier at the World Cup.
It's a game of rugby and a game we all love because of the attritional side of it. It's not touch it's not football.
When the whistle goes it's 15 versus 15. We have experience and hopefully we can bring that to bear. Hopefully it will be a good advert for the Six Nations."
Cardiff prepare to take on Fulham at the Cardiff City Stadium later. It's Cardiff's first home game since their 4-0 defeat against Hull, and Manager Ole Gunnar Solskjaer has branded it a "big game".
Fulham are currently the only side below Cardiff in the Premier League.
Speaking at a media conference, Solskjaer said: "Neither team wants a draw, we both need a win. That's the nature of the game... and the pressure is on Cardiff because they're at home."
Wales' Under 20s suffered a crushing defeat against their English counterparts. The home side outscored the visitors by ten tries to one, leading 38 nil at half time. Flanker Gus Jones crossed four times for England. A late penalty try and conversion was all Wales had to show for their efforts.
England: Taylor, Thacker (2), Jones (4), Kibirige, Lundberg, Itoje; Convs: Burns (6), Olver; Pen: Burns
Wales: Try: Penalty; Conv: Price.
Wales lock Luke Charteris has been forced out of Sunday's clash with England.
In his place is Scarlets forward Jake Ball for his second Six Nations start.
He comes into a side who have recovered well from their defeat to Ireland earlier in the championship, a turn around which means that with two games left to play Wales' hopes of a third consecutive Six Nations title are very much alive.
Cardiff City manager Ole Gunnar Solskjaer has defended club owner Vincent Tan over a row which saw him offer the squad a £3.7m bonus payment last weekend, if they avoided relegation from the Premier League.
Mr Tan withdrew the offer when he realised that it breached league rules.
The Bluebirds face Fulham - the only side below them in the table - tomorrow, in what is being billed as a relegation six-pointer.
Second row Luke Charteris has been ruled out of Wales' clash with England on Sunday, with a neck injury.
Scarlets' lock Jake Ball takes his place, alongside fit-again Alun Wyn Jones.
Andrew Coombs will be on the bench for Sunday's game at Twickenham.
England have made one change to their team to face Wales in the Six Nations on Sunday.
Former Scarlets number 8 Ben Morgan replaces the injured Billy Vunipola.
Tom Johnson comes onto the bench for the game at Twickenham.
Centre Manu Tuilagi has recovered from long-term injury but is not considered for selection due to a lack of match fitness.
England head coach Stuart Lancaster said: "We can't wait to play at home again. The players have said that the atmosphere at Twickenham for the Ireland game was the best they had experienced and I'm sure it will be the same again on Sunday."
"It definitely gives us an extra lift and that's what we want against another experienced, high-quality side, who are looking to defend their title."
On the latest episode of ITV Cymru Wales' In Touch programme, Frances Donovan has an in-depth interview with Wales manager Chris Coleman.
He spoke about managing the world's most expensive footballer - Gareth Bale, his hopes of qualifying for Euro 2016 and the behind-the-scenes moves over his new contract with Wales.
Wales manager Chris Coleman said after last night's friendly against Iceland,"I have just asked him (Bale) for an autograph!
"He is one of the best I have ever witnessed. He is an unbelievable player, he really is. He is a fantastic weapon for us."
The Real Madrid forward was the star attraction at the Cardiff City Stadium and lived up to his billing as he scored a magnificent solo goal and created two others.
James Collins opened the scoring when he headed home from a Bale free-kick and Sam Vokes snaffled a second.
Bale wrapped up victory when he sprinted down the touchline from inside his own half and then cut in to drill home a low shot.
Unfortunately for the Football Association of Wales, only 13,290 did turn up for what seemed a low-key affair.
Yet while it might not have been the Bernabeu or the Champions League, Bale showed no little enthusiasm for the challenge in the 72 minutes he was on the field. Coleman said Bale "was worth the admission on his own."