A crowd of 74,000 people is expected to swarm to the Millennium Stadium today for the first game of this year's Six Nations tournament.
Defending champions Wales will take on Ireland at 1.30pm in Cardiff.
Losses against Australia (four times), New Zealand, Argentina and Samoa mean that Wales are experiencing their most barren run for nine years and go into this season's tournament as fourth favourites behind France, England and Ireland.
Captain Sam Warburton believes Wales will take "massive confidence" from their status as reigning RBS 6 Nations champions when they aim to end their losing run.
Wales have not beaten another Test-playing country since defeating France to secure last season's Six Nations title and a third Grand Slam in eight years.
Ireland are first up at the Millennium Stadium, a reversal of last year's opening fixture in Dublin when Wales prevailed thanks to full-back Leigh Halfpenny's late penalty strike.
Despite a lengthy injury list that currently includes the likes of Ryan Jones, Rhys Priestland, Richard Hibbard, Alun-Wyn Jones, Luke Charteris and Bradley Davies - plus head coach Warren Gatland's absence due to British and Irish Lions commitments - Warburton remains in upbeat mood.
Interim head coach Rob Howley insists Wales won't shy away from competition as a result of recent rugby victories.
"We're Six Nations champions and Grand Slam winners. We need to back that up. We're not going to hide away from it," he told ITV.
Captain Sam Warburton believes it could be a 'tough ask' for Wales to secure a second consecutive Six Nations win - but says they're ready for the challenge.
He told ITV that Wales would focus on each game as it happened, adding: "No match is an easy match - but that's what makes it so exciting."
Today marks the official launch of the 2013 Six Nations tournament.
Wales are the current defending Six Nations Champions and will play their first match of the competition against Ireland in February.
The captains and coaches of all Six Nations squads will travel to London for the official launch later today.