Prop Gethin Jenkins has been ruled out of Wales' RBS Six Nations Championship match against Scotland on Saturday due a calf muscle injury, the Welsh Rugby Union has announced.
Rob Howley is set to name a familiar looking side to take on Scotland in this weekend's Six Nations meeting in Edinburgh.
Howley is not expected to tinker with the winning formula that has seen Wales rise from Tournament Cast-Offs to Championship Contenders over the past few weeks.
A win in Scotland would set up the tantalising prospect of a final week decider against England in Cardiff, should Stuart Lancaster's side continue their current winning form against Italy.
Despite leaving out a number of first-choice regulars for the trip to Rome Howley has a more difficult decision ahead of him against a Scotland side who have shown their ability in both attack and defence, after wins against Ireland and Italy.
Fit-again lock Alun Wyn Jones will be one name that will be hard to overlook, although the form of his understudy Andrew Coombes gives the Wales staff plenty of food for thought. In the back row a resurgent Sam Warburton will be eager to reclaim his spot from Osprey Justin Tipuric.
The coaching staff are understood to be waiting on the fitness of prop Gethin Jenkins before making a final decision, although Defence Coach Sean Edwards revealed that he is making steady progress from a calf injury. Should he fail to pull through Paul James is the likely replacement.