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Brothers Kyle and James Smith from the Vale of Glamorgan were both travelling in the same car which crashed in 2005.
Kyle was 16, not wearing a seatbelt, thrown from the vehicle and died.
James was 15, wearing a seatbelt and survived.
Their mother Angie Smith says she has "no doubt" that she would have lost both boys, had James not been wearing a seatbelt.
This year’s campaign is backed by Angie Smith, whose sixteen year old son Kyle was killed in a car crash in 2005. He was not wearing a seatbelt.
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The mother of a teenager who died in a crash when he wasn't wearing a seatbelt has added her voice to the 'Belt Up!' campaign.