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Andy Furey is the National Officer for Communication Workers Union, which represents staff working in Crown Post Offices.
He told ITV News: "A Welsh town like Holywell needs a Crown Post Office. If we lose it, this could be the death knell for the high street in Holywell."
Delyn MP David Hanson has told ITV News more detail is needed regarding proposals to franchise Holywell's Crown Post Office.
"Part of tonight's meeting is to hear from local people as to what they think of the service," he added.
The Post Office says its 370-branch crown network is losing £37million a year, which cannot be sustained.
Delyn MP David Hanson will be among the speakers at this evening's meeting. He says the future of Wales' crown post offices needs to be protected.
Campaigners against plans to franchise Holywell's Crown Post Office will hold a public meeting later.
The High Street branch is one of eight being considered for franchise out of 20 Crown Post Offices across Wales - leaving 12 by 2015.
The Post Office said it is committed to keeping branches on high streets across the UK, pointing out that around 98% of the total network in Wales already operate successfully through franchises and agreements with retailers.
But Communication Workers Union, the trade union representing staff working in Crown Post Offices, says Post Offices are 'key attractions' in town centres and believes there are ways to keep Holywell's open.
A petition has also been signed by thousands of people objecting to the plans.
The meeting will be held at Holywell Leisure Centre from 6pm.
Latest ITV News reports
A public meeting will be held this evening over plans to franchise Holywell's Crown Post Office.