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The Dragons maintained their perfect record at Rodney Parade with a comfortable win over Italian side Zebre. 18 year old winger Hallam Amos crossed twice as Lyn Jones' men notched up their third win of the campaign. Lewis Evans also scored, with Jason Tovey kicking 15 points.
The Ospreys went top of the RaboDirect pro 12, but slipped to defeat against Ulster at the Liberty Stadium. In an game dominated by defence, Dan Biggar kicked four penalties for the home team. But he was outdone by his opposite number Paddy Jackson, who succeeded with all six of his shots at goal.
The Dragons face Italian side in the PRO12 at Rodney Parade tonight.
The Newport side have made a promising start to the season under new director of rugby Lyn Jones, with victories against Ulster and the Scarlets, but defeat to Munster and Edinburgh.
Zebre claimed their first win since being formed, with a thrilling 30-25 victory over Cardiff Blues a fortnight ago.
The Italian side were founded in 2012, and lost every match in their debut PRO12 season.
Lions No8 Toby Faletau is back in the Dragons' line-up, one of several changes in the forwards.
Second row Rob Sidoli, who makes his first start of the season, said: Zebre have "improved a lot. I think that they are a genuine threat as they had a really good result against the Blues which was away for them."
"They have some really good individuals and their core basics are very strong; they will have a good driving line outs and scrum so those are the things we need to get up to speed on quite quick.”
The Ospreys will look to maintain their unbeaten PRO12 start when they host Ulster at the Liberty Stadium tonight.
The Irish side were beaten PRO12 finalists last season, but have had a mixed start to their campaign.
They are currently fourth in the table - with the Ospreys second.
The Welsh side have Lions stars Richard Hibbard, Adam Jones, Alun Wyn Jones, Ian Evans and Justin Tipuric in their XV.
Canadian flanker Tyler Ardron makes his first start for the Ospreys.
Ospreys Head Coach Steve Tandy said: "We are really pleased to be where we are in the table four weeks in and after three games on the road, but we aren’t going to allow ourselves to get carried away. There’s plenty of room for improvement."
"Ulster is as difficult as it gets. They’ve got a strong squad with world class players in there."