Warren Gatland has made three changes to his side to face Ireland in Dublin.
Gethin Jenkins, Andrew Coombs and Sam Warburton all come into the fold, while Rhys Priestland and Scott Williams keep their places in the back line.
WALES SQUAD TO PLAY IRELAND: Leigh Halfpenny (Cardiff Blues), Alex Cuthbert (Cardiff Blues), Scott Williams (Scarlets), Jamie Roberts (Racing Metro), George North (Northampton Saints), Rhys Priestland (Scarlets)
Mike Phillips (Racing Metro), Gethin Jenkins (Cardiff Blues), Richard Hibbard (Ospreys), Adam Jones (Ospreys) Andrew Coombs (Newport Gwent Dragons), Alun Wyn Jones (Ospreys), Dan Lydiate (Racing Metro), Sam Warburton (CAPT – Cardiff Blues), Taulupe Faletau (Newport Gwent Dragons).
Replacements: Ken Owens (Scarlets), Paul James (Bath Rugby), Rhodri Jones (Scarlets), Jake Ball (Scarlets), Justin Tipuric (Ospreys), Rhys Webb (Ospreys), James Hook (Perpignan), Liam Williams (Scarlets).
Wales take on Ireland in Dublin on Saturday after defeating Italy 23 - 15 last weekend.
Warren Gatland names his Wales team later to face Ireland at the Aviva Stadium.
The encounter could go some considerable way towards determining the outcome of this season's Six Nations tournament.
Wales have won three of the last four encounters.
The clash is given added spice by the fact that Wales head Warren Gatland controversially omitted O'Driscoll from last summer's British and Irish Lions Test series finale against Australia.
Gatland, in his role as Lions supremo, opted for an all-Welsh midfield pairing of Jonathan Davies and Jamie Roberts in a game the tourists won 41-16.
But the non-selection of O'Driscoll caused an outcry among Irish supporters and some rugby pundits.
Wales centre Jamie Roberts says he's glad to be back in the red jersey, but insists Wales will need to improve if they're to defeat Ireland in Dublin next weekend: "We have to be pleased with the win," said Roberts after the 23-15 victory over Italy.
"International rugby's about winning, and we're one from one. But we know we have to be at our best next week. Ireland are going to be a formidable outfit, certainly in Dublin. It's a huge game." Roberts was speaking after his first Wales appearance since last year's title decider against England.
The Lions man had been forced to sit out the Autumn internationals with injury. But he made a bright return, running strongly throughout the game and feeding centre partner Scott Williams for Wales' second try.
"I've got very fond memories of the Millennium Stadium. It's a magical place to play, and today was no different. They stopped the music half way through the anthem and it's just amazing."
"You've got the harmony from the choir - it's completely unique as a player to play in the red shirt and it's an absolute privilege to get that chance again today."
"You don't appreciate what you've got till it's gone. Having missed the Autumn series it just makes you desperately hungry to be back in that Wales shirt. Hopefully today I did it proud."
With Roberts' fellow Lions centre Jonathan Davies returned to fitness, there's debate over which midfield partnership coach Warren Gatland will favour to face the Irish on Saturday.
"All of us know three into two doesn't go. With Jon back in the selection mix this week it's going to be an interesting selection going into the Ireland game."
The Wales team to face Ireland is due to be named tomorrow morning. And the Racing Metro centre is under no illusions about the task ahead.
"As a back line they're very, very efficient. They're a great team, they're very skillful players and they play very well together. This week it's about preparation, it's about doing our homework and righting the wrongs of the performance against Italy."
Wales head coach Warren Gatland says it's great Wales have one game 'under their belt but that every game is gonna be tough.
Wales have got off to a winning start in the Six Nations, with a 23 - 15 win over Italy at the Millennium Stadium.
Wales' Six Nations campaign has got off to a successful start at the Millennium Stadium in Cardiff.
Half time score: Wales 17 - 3 Italy