Centre Jonathan Davies and Prop Adam Jones have been ruled out of the rest of Wales' Autumn International campaign, the WRU have confirmed.
Davies left the field during Wales 15-24 loss to South Africa on Saturday after damaging a pectoral muscle during the build up to the Springbok's opening try.
Jones limped out of action in the first half of the same game after damaging a calf muscle.
Wales international Adam Jones has tweeted to criticise the WRU for banning a referee following a comment made on the social networking site.
Adam Jones said that "maybe If the WRU worried about themselves and the regions sorting their c**p out and not banning a ref for tweeting we may get somewhere!"
Hugh Watkins resigned live on the BBC's Scrum V programme after he was banned for 12 weeks after he questioned the decision by the referee in the Hong Kong Sevens final between Wales and Fiji not to show a red card for a dangerous tackle.
The WRU have told ITV News that they don't want to comment further at this time as disciplinary action is currently being taken.