The Welsh Government says the number of drug-related deaths in Wales has fallen by 30% over the last five years
Deaths from drug misuse in 2014 fell by 16% compared to 2013 and by 30% since 2010.
The drug misuse mortality rate in Wales has also fallen by 16% compared to 2014, to 39 deaths per million – the lowest rate since 2006.
Three people who fell ill after taking the drug Mephedrone are likely to have been affected by the amount consumed and not because the drug was contaminated, according to a Public Health Wales investigation.
Two were admitted to intensive care following the incident earlier this month. One has now been discharged but the other remains critically ill.
Laboratory tests on the drug have ruled out any contamination and the investigation has now concluded.
A short film aimed at raising awareness of the dangers of drugs will premiere at a cinema in Brynmawr tonight.
'The Good Drug Dealer' focuses on the impact that substances, such as Mephedrone, can have on families and communities.
The hour-long production comes off the back of a campaign by project researcher Jeff O'Reilly to get the substance banned as a legal high.
Gareth David Lloyd from Torchwood and Darren Evans from My Big Fat Diary both star in the drama.
Those backing the project, including police and local authorities, say it 'pulls no punches' in its drive to raise awareness of substance misuse.
Any proceeds from the film will be re-invested to the local charity People and Communities Engaged.
An undercover ITV Cymru Wales reporter has exposed the extent of Llanelli's drugs problem, obtaining a gram of the class B drug Mephedrone, after just an hour on the streets of the town.
Recent figures show that of a hundred offences committed relating to the drug - commonly known as Meow Meow - in Carmarthenshire in just six months nearly half were in Llanelli.
The investigation is part of a special Hacio programme to be broadcast on S4C at 10pm on Wednesday.
Dyfed-Powys Police admits drugs are "an issue" in Llanelli, and says tackling drug misuse and supply is "a priority" for the force.
An ITV Cymru Wales reporter has been undercover to reveal the extent of the drugs problem on the streets of Llanelli.
After spending less than an hour in the West Wales town, our reporter had managed to obtain a gram of the class B drug Mephedrone.
The investigation is part of a special programme on the drug scene in Llanelli, to be broadcast on Hacio on S4C at 10pm on Wednesday.
Dyfed-Powys Police and Crime Commissioner Christopher Salmon has acknowledged the scale of the problem.
North Wales Police believe a 19-year-old man who died on Saturday had taken "a quantity of tablets", which they believe he had been sold "by an individual within the local area."
The death of Thomas Jones from Llangefni is currently being treated as "unexplained."
Police are investigating whether his death is linked to what they believe is a form of ecstasy called "Green Apples."
DCI Andrew Williams he is "absolutely desperate to ensure that nobody else loses their life as a result of taking these tablets."
Anyone with information about people who use or supply "Green Apples" or any other controlled drug is asked to contact North Wales Police on 101, or Crimestoppers on 0800 555 111.
A drug charity has told ITV Cymru Wales that one of their biggest battles is fighting against new and unknown drugs.
The message comes after the death of 19-year-old Thomas Jones from Llangefni after he was thought to have taken a drug with the street name "Green Apples" - believed to be a form of ecstasy.
Endaf Evans from charity CAIS says that experts are fighting often against new and unknown substances.