Gareth Bale is to undergo surgery on the ankle injury he suffered during Tuesday's Champions League win over Sporting Lisbon, Real Madrid have announced.
The Wales international was replaced just before the hour mark during the 2-1 victory in Portugal and tests on Wednesday revealed he had suffered damage to his tendons.
Real have now announced the 27-year-old will go under the knife in London next Tuesday.
The European champions have not said how long they expect Bale to be sidelined for, but reports in Spain suggest he could be out for up to three months.
Wales' next scheduled match is the World Cup qualifier against the Republic of Ireland on March 24th.
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Wales captain Ashley Williams accepts there is no more margin for error in the pursuit of World Cup qualification.
Serbia's late equaliser in a 1-1 draw in Cardiff on Saturday night left Wales with an uphill battle to reach the 2018 finals in Russia.
The Euro 2016 semi-finalists - who have let leads slips to draw their last three qualifiers - are now four points adrift of Group D leaders the Republic of Ireland and two behind second-placed Serbia.
Wales next head to Dublin in March.
We have to win now. But it's not all doom and gloom.
We haven't lost in the campaign yet and we feel we can go on and beat any team. If we have to win all of our games we're confident we can do that.
Every game is getting bigger and bigger, and when you don't win it's frustrating, to take the lead again and not win the game and keep a clean sheet.
We're a team that have come so far that we expect to win games, especially at home, but we didn't.
Wales manager Chris Coleman says the team are devastated after their hopes for World Cup qualification were dented last night against Serbia.
Wales had to settle for a point after a last minute equaliser from their opponents at the Cardiff City Stadium.
“I think we deserved three points, I thought we managed the game very well”, Coleman told ITV News.
It's not like they were causing us too many problems so we're devastated to be fair to have dropped those two points. I thought the players deserved more than what they got but that's football, you don't always get what you deserve.
I think the biggest disappointment is when you get so close to taking all three, and you deserve to take the three, to hit the post at one end and then seconds later they grab the equaliser so late in the game. You know, and that's a tough one to swallow.
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