Labour Leader Jeremy Corbyn has said he understands Jo Stevens' difficulty with being asked to vote in favour of triggering Brexit. But in his response to her resignation, he said it was right that their party respected the referendum result.
Westminster reaction to Jo Stevens' resignation has included this supportive tweet from Labour peer and former Welsh Secretary Peter Hain.
One of the ministers she faced in the Commons has also praised her work as shadow Welsh Secretary -before highlighting Labour's troubles,
The Liberal Democrats, who lost Cardiff Central to Jo Stevens in the 2015 General Election, were similarly unable to resist focussing on Labour's difficulties.
Plaid Cymru questioned Labour's commitment to representing Wales at Westminster after losing its fourth shadow Welsh Secretary in two years.