A hundred and seventeen jobs will be lost at Jeyes cleaning supplies factory in Mold, it's been announced.
Unemployment in Wales has fallen by 1,000, in the first three months of the year.
Zurich Insurance has confirmed 342 jobs are to go at five of its UK offices, including 113 in Cardiff.
£4 million is being spent on helping nuclear energy workers in North West Wales back into work.
The funding aims to help 1,200 staff at the Wylfa and Trawsfynydd sites prepare for future careers.
Wylfa, on Anglesey, is due to stop generating electricity in 2014. Trawsfynydd has already closed, and is in the process of being decommissione d.
The funding comes from the European Social Fund, the Welsh Government, the Nuclear Decommissioning Authority and local councils. Workers will be given career advice, mentoring, training and job-search help.
Hopes for a new power station at 'Wylfa B' were set back last month when two leading power companies withdrew their plans for the site.
Almost 150 jobs could be cut in the Valleys by the retailer Peacocks.
Peacocks has proposed cutting 147 jobs in three of the distribution centres in the South Wales Valleys. The company hopes the final figure of job losses will be much less.
Peacocks employs 660 people at the sites in Nantgarw, Pentre in the Rhondda and in Merthyr Tydfil.
Recently the Cardiff-based firm was sold out of administration by Edinburgh Woollen Mill (EWM). In February, 6000 jobs were saved but 3100 staff were made redundant.
A spokeswoman said: "Our aim is to have as few redundancies as possible. This is a process we have to go through but we are hoping the final figure will be much less."
The company hopes extra work can be found for staff at the distribution centres within the EWM group or that the staff can be deployed elsewhere.
1,000 extra people were unemployed in the three months up to February, according to figures from the Office of National Statistics (ONS).
The total number of people out of work in the period stood at 131,000, a rate of 8.9%.
600 more people were claiming Jobseeker's Allowance compared to last month's figures. The overall rate stayed the same at 5.6%, putting Wales 0.7 points above the national average.
The latest unemployment figures are due out later today. Last month, they showed the number of people in Wales out of work rose slightly, to reach a hundred and thirty four thousand, in the three months to the end of January. The unemployment rate is higher in Wales than across the UK as a whole.
Rosie French tells our Business Correspondent Carole Green that she could only find temporary work waitressing until she joined the Jobs Growth Wales pilot scheme at a call centre in Carmarthen.
The 'Jobs Growth Wales' scheme should deliver permanent jobs for young people, the First Minister, Carwyn Jones AM, tells our Business Correspondent Carole Green.
More than two hundred Welsh jobs have been secured, with the sale of the family-owned supermarket and convenience store chain Harry Tuffins. The Midcounties Co-operative, based in Warwickshire, has agreed to buy the chain.
Harry Tuffins' headquarters are at Churchstoke in Powys, where it employs 80 people. It has 81 members of staff at Knighton, Powys, and 27 at Machynlleth, Powys, as well as 16 at Holywell, Flintshire.