Cardiff University has become the first university in Wales to be accredited as a Living Wage employer.
It means all staff will receive a minimum hourly wage significantly higher than the national minimum wage of £6.50.
Wales TUC says nearly a quarter of jobs in Wales pay less than the living wage.
Their General Secretary, Martin Mansfield, said working families are facing the biggest pressures since Victorian times.
Wales TUC says close to a quarter of jobs in Wales pay less than the living wage.
Their analysis of official figures revealed 23% of Welsh workers are paid below the living wage - a higher share than in any other UK nation or region.
It also found the concentration of low paid work varies across parliamentary constituencies.
For example, Dwyfor Meirionnydd and Rhondda top the table of pay blackspots with 39.9% and 39.7% of those working locally, earning below the living wage respectively.
For working women, the picture is even bleaker, with around 46% of women working in Dwyfor Meirionydd taking home less than the living wage.
Today marks the 15th anniversary of the introduction of the National Minimum Wage.
Around 285,000 working people in Wales would be better off if their employers paid a 'living wage' of £7.45 an hour says the TUC Wales.
The minimum wage for over 21s outside of London is currently £6.31.
The union says if every worker in Wales was paid a 'living wage' the UK Government would save £154 million through reduced spending on benefits and a boost in taxes.
Welsh employers are being told that low wages weaken the Welsh economy and leave working families in poverty.
Only 14 employers in Wales have signed up to the Living Wage and pay their staff a minimum of £7.45 - they include housing associations, Cardiff and Caerphilly Councils and the Welsh Government which employs 5,500 people.
Wales TUC President, David Evans said, "Some large companies are getting away with underpaying their staff as means tested benefits and tax credits top up incomes. Good employers continue to be undercut by bad ones and now more than ever, workers across Wales need a pay rise."
Earlier this week Mayor of London Boris Johnson announced that council staff at City Hall in London would get the Living Wage.
Johnson said the new rate will be worth £4.5m a year for lower-paid workers.