Sale ripped top spot in Pool 2 and a home quarter-final in the European Challenge Cup away from Newport Gwent Dragons with a 38-5 bonus-point victory at AJ Bell Stadium.
The Sharks had the victory all but sewn up inside the opening 20 minutes when, after Newport had lost Wales wing Hallam Amos to the sin-bin, they raced into a 17-0 lead through a Brian Mujati score and a penalty try.
The Dragons got on the board themselves through Ashton Hewitt's try on the hour but Sale had the final word when Mike Haley cruised over for his side's fifth try.
Adam Hughes has re-signed with Newport Gwent Dragons until 2018.
The 25-year-old centre returned on loan from Exeter Chiefs for three months in October and has started every game since his return.
The former Wales Under-20 made his first appearance for the NG Dragons in 2010 before joining Bristol four years later.
Director of Rugby, Lyn Jones says it's an "important signing as they move forward.”
Newport Gwent Dragons Director of Rugby, Lyn Jones, has signed a new two-year deal, keeping him at the club until June 2017.
The former Wales flanker was appointed in June 2013 after his time as head coach at London Welsh.
Newport Gwent Dragons have confirmed that Ashley Smith has retired on medical grounds with immediate effect.
The club says Smith has suffered a series of concussive events and after expert advice he has decided to hang up his boots.
The Dragons academy product was identified at an early age as he went on to represent Wales throughout the age grades and captained the U20s in the 2007 Six Nations Tournament.
The 28-year-old began his time with the Region in 2005 and has made an outstanding contribution with over 160 appearances for the Dragons. Before his time with the Men of Gwent, Smith made a number of appearances for premiership side Newport RFC.
Newport Gwent Dragons centre Ashley Smith has undergone surgery after suffering a fractured jaw during last nights European Rugby Challenge Cup victory over Bucharest Wolves.
Smith suffered the injury in the first minute of the 69 - 17 win at Rodney Parade.
The 27 year-old was assessed at the ground and then taken to hospital last night where he has undergone surgery to have plates put into his jaw this morning.
The region say their medical staff and doctors are currently monitoring him and will have a further update on his recovery in 2-4 weeks.
Newport Gwent Dragons got Wales' weekend of European rugby off to a winning start, seeing off their Romanian opponents 37-10 in Bucharest.
Despite finding themselves 10 - 0 down early on, five tries were enough to secure a bonus point win for the Welsh team.
Ashley Smith, T Rhys Thomas and James Thomas all touched down, while Andrew Coombs got two.
Glasgow Warriors reclaimed a top-four place in the Guinness PRO12 after a hard-fought 19-15 victory over Newport Gwent Dragons at Scotstoun.
Having lost to Scarlets in the last round of games, it was not a spectacular response from Glasgow whose coach Gregor Townsend will know his men must play better to mount a serious challenge for the silverware this season.
If the Welsh visitors had capped a spell of sustained pressure in the closing 10 minutes, there could have been few complaints in the home camp.
Glasgow's points came from a penalty try and a 14-point contribution with the boot by Duncan Weir.
For the Dragons, who now sit second from bottom, Geraint Rhys Jones landed five penalties in an immaculate kicking performance.
Newport Gwent Dragons were beaten 16-11 in their PRO12 season opener at Connacht.
Nic Cudd scored the Dragons' try in the first half, to cancel out Eoin McKeon's early score for the Irish team.
Connacht got on top during a crucial second half spell when Lee Byrne and Tyler Morgan were both sent to the sin bin.
Danie Poolman touched down, and Darragh Leader kicked another penalty to pull them clear.
A late penalty from Jason Tovey earned the Dragons a losing bonus point in Ireland.