Drugs to treat the central nervous system - including painkillers - cost the NHS in Wales more than any other type of drug last year.
Parents of Welsh youngsters with cerebral palsy say their children are being denied a potentially live-changing operation.
As the NHS enters its 66th year, we've been looking at the pressures the service is under and hearing from those who rely on it.
The wilful neglect of patients will be made a criminal offence in Wales under NHS reforms being introduced in the wake of the Mid Staffordshire and other care scandals.
David Cameron said health workers who mistreated and abused patients would face "the full force of the law" in a package of measures to be unveiled next week.
Cwm Taf health board has tweeted to advise patients that A&E services at Royal Glamorgan are under pressure.
It has asked those with minor injuries to visit Ysbyty Cwm Rhondda instead, which is just under 10 miles away.
Royal Glamorgan Hospital A&E is very busy today. If you have a minor injury please call 01443 444 075 for appointment at Ysbyty Cwm Rhondda
It comes ahead of a debate by Assembly Members later on how to prepare the Welsh NHS for another busy winter.
A debate will be held in the Senedd later on how to prepare the Welsh Health Service for another busy winter.
Last week David Sissling, the Chief Executive, revealed to the Public Accounts Committee that the service was only just catching up with the backlog of cancelled operations caused by last winter's surge in demand.
In October, Hywel Dda Health Board outlined plans to stop some non-urgent operations over winter months.
There has been further evidence of the pressure on health service budgets today, with muscular dystrophy patients calling for extra funding for the treatment of the condition.
They say that an extra £650,000 could save the NHS here millions in the long run.
Families from across Wales will be gathering at the Assembly today to demand NHS funding for rare muscular conditions.
The Welsh Government says the NHS is facing "significant" financial challenges.
In a recent meeting with the Muscular Dystrophy Campaign to discuss the Welsh Neuromuscular Network Vision Document, the Health Minister referred to the significant challenges facing the NHS in Wales and that these challenges would continue for some time to come.
While he expressed his support for their work, the Health Minister also acknowledged any developments in services would have to come about from new ways of working as it is unlikely any additional financial resource will be available.
– Welsh Government Spokesperson
We understand that patients with a long term neurological conditions such as muscular dystrophy need access to complex and well co-ordinated services. This is why we commenced last week a consultation on a draft Neurological Conditions Delivery Plan. We urge the Campaign and indeed all individuals with an interest in neurological conditions to contribute."
People who suffer with muscular dystrophy are campaigning for more NHS funding in care services, which they are calling "desperately overstretched."
Patients, assembly members and health professionals are calling for an investment of £650,000 to cover the current shortfall of care services.
A report by the Welsh Neuromuscular Network has found a lack of specialist health workers is leading to high rates of emergency care.
Campaigners are meeting at the Senedd today to present the report's findings to the Welsh Government.
The Welsh Health Minister, Mark Drakeford, has ordered an independent review into Abertawe Bro Morgannwg University Health Board.
It'll pay particular attention to the Princess of Wales and Neath Port Talbot Hospitals.
In the past the health board has said it's made improvements at the hospitals with more nurses and better training.
Welsh Liberal Democrat leader Kirsty Williams has urged the Welsh Government to take the findings of Ann Clwyd's report seriously and not 'continue to stick its head in the sand.'
This review happened because the Coalition Government took Ann Clwyd’s harrowing story about the treatment of her husband seriously. Despite his mistreatment being in a Welsh hospital, the Coalition acknowledges that these problems are UK wide. Yet what has the Welsh Labour Government done? Nothing. Their inaction has been shameful.
While the Coalition Government is acting to improve health care in England, the Welsh Labour Government continues to pretend all is well. Things won’t improve until the Welsh Labour Government acknowledges the sheer scale of the problems our NHS faces.
– Kirsty Williams AM, Welsh Liberal Democrat leader
Ann Clwyd has explicitly said that that Wales is behind in ‘every instance’. If even one of Labour’s own MPs is saying this, surely the Welsh Labour Government should start listening.
The Welsh Conservatives have welcomed Ann Clwyd's call for an inquiry into Welsh hospitals with higher-than-average mortality rates. They say her call backs their own demand for an investigation similar to one led by Sir Bruce Keogh in England.
Opposition Leader Andrew RT Davies said:
Ann Clwyd is a well-respected campaigner on standards in our NHS and I welcome her support for a Keogh-style inquiry into the Welsh NHS.
Successive reports of failings in NHS care, C-Difficile outbreaks, worsening waiting times all deserve thorough investigation and the way to do that is though an independent inquiry.
– Andrew RT Davies AM, Opposition Leader
Patients deserve the highest levels of care and NHS staff deserve to work in conditions with the resources to reasonably deliver those standards.
You cannot put a price on a life and I hope these calls will encourage Carwyn Jones to revise his original rejection of a Keogh-style inquiry on cost grounds