Drugs to treat the central nervous system - including painkillers - cost the NHS in Wales more than any other type of drug last year.
Parents of Welsh youngsters with cerebral palsy say their children are being denied a potentially live-changing operation.
As the NHS enters its 66th year, we've been looking at the pressures the service is under and hearing from those who rely on it.
Ann Clwyd has called for an investigation into high mortality rates in Welsh hospitals similar to the Keogh Inquiry for England. The Cynon Valley MP has published her report into the way complaints int the NHS in England, calling for a 'revolution' in the way patients' concerns are dealt with.
She says she's 'confident' that the Welsh Government will want to follow some of her recommendations and says she's had regular meetings with the Welsh Health Minister. She's also due to meet the First Minister next week.
But she says she hopes there'll be 'something similar to Sir Bruce Keogh's review in England' which investigated 14 hospitals with high mortality rates. She told our Political Editor Adrian Masters that high mortality rates are 'a smoke signal for something that's wrong.'
GPs in Wales say they're concerned about their ability to provide quality care for patients as they claim they face a £25m "black hole" in funding.
They warn of longer waiting times for GP appointments, a cut in services and greater workloads for doctors if more cash is not made available.
The Royal College of General Practitioners say latest figures reveal that the amount spent in general practice per person has dropped by 7.6% in real terms between 2008 and 2012, due to a combination of funding cuts and population growth.
For the fourth year running, GP surgeries in Wales have suffered a decrease in resources, with real terms investment in general practice falling to £469m in 2012/13 from £495m in 2008/09 they say.
Paul Myres, Chair of the RCGP in Wales said, “Many are practising from inadequate premises and are increasingly unable to meet the needs of patients. The Welsh Government has recognised that there are areas of Wales where health care is not meeting the additional needs of deprived communities."
Nearly half of GPs had already had to cut back on the range of services they provide for their patients and over 70% predicted longer waiting times for GP appointments within the next two years says the college.
The First Minister has faced sustained criticism in the Assembly chamber from all three opposition party leaders over a health board's plans to cope with winter pressures. Hywel Dda health board says it will reschedule some non-urgent operations in order to focus on emergency surgery.
At First Minister's Questions, Carwyn Jones was criticised by the Conservatives, Plaid Cymru and Liberal Democrats who said the plans would lead to further worrying delays for patients. But Mr Jones said Hywel Dda's proposals stemmed from sensible planning:
– Carwyn Jones AM, First Minister of Wales
We are planning for winter pressures. Local health boards are planning for an appropriate number of operations that create the capacity to deal with emergencies in the future.
At first glance it seems every other Welsh Government department will see its budget cut in order to pay for the increase in spending on the NHS. It adds up to £100m cut for 2014/15. Local government takes the biggest hit, losing £98m from its allocation for 2014/15. The other departmental cuts are:
- Economy, Science Transport - £26.9m
- Education and Skills - £77.5m
- Natural Resources and Food - £22.2m
- Housing and Regeneration - £6.6m
- Culture and Sport - £4.3m
- Central administration - £4.1m
The man in charge of the NHS in Wales has released his annual report and, despite a year of conflict and controversy across the service, it paints an upbeat picture of progress on many fronts.
David Sissling accepts there were "unprecedented pressures" on NHS Wales last winter.
He also says that acknowledging shortcomings can be "uncomfortable" - but much of the report highlights impovements not problems.
So, is it a system in crisis or a time of rapid improvement?
Andrew RT Davies, leader of the Welsh Conservatives, says investment, "clear leadership and direction" is needed from the Welsh Government for the NHS here.
Speaking to our Health Reporter Rob Osborne, he reiterated his call that an inquiry is needed into standards of care, similar to that carried out by Sir Bruce Keogh into high mortality rates in England.
NHS Wales Chief Executive David Sissling has insisted there does not need to be a major inquiry into the health service here, as the organisation is already doing a lot of work to review and improve.
There have been calls for an inquiry into the standards of care in the NHS in Wales, particular after it was 12 people have died over the last 15 months while waiting for cardiac surgery at the University Hospital of Wales in Cardiff.
Critics have demanded a major inquiry, similar to the one carried out by Sir Bruce Keogh, NHS Medical Director in England, into 14 hospital trusts with unusually high mortality rates there.
Mr Sissling told our Health Reporter Rob Osborne: "We're looking mortality rates and other indicators of quality care, we're bringing to bear external expertise where we need to do so, we're bringing the voice of the patient, the influence of our staff to bear."
"So in a sense we're undertaking this work, and we're doing it across all of the health system, not just looking at a very small percentage of hospitals and organisations. We're doing it for every part of the health service in Wales."
The annual report from the Chief Executive of the NHS in Wales has acknowledged that it has been "a challenging year indeed", with "unprecedented demand" on services during the winter period.
David Sissling has insisted though that there has been improvements to the health service here in "a year of progress".
He said there has been progress on reducing healthcare associated infections, like C.difficile and MRSA, and reducing pressure points in hospitals.
He said the NHS had been more transparent, publishing new data on mortality and infection rates.
Patients in Wales are being put at unnecessary risk, because health boards aren't taking action to deal with safety alerts. That's according to Freedom of Information requests from the charity Action Against Medical Accidents.
None of Wales' health boards have hit all of their deadlines to comply with so-called patient safety alerts - which are issued when things have gone wrong in the NHS, such as mistakes with high-risk medicines or giving the wrong type of blood. Tom Sheldrick reports.
Mandy Collins, deputy chief executive of Health Inspectorate Wales, says she is meeting with Action Against Medical Accidents chief executive Peter Walsh to discuss what more can be done to address issues raised in the report.
She told ITV News there is always room for improvement and Health Inspectorate Wales wants to learn from the report.
A Welsh Government spokesperson said: "We welcome scrutiny of patient safety - this is a matter we take very seriously. While it is encouraging that NHS organisations have made major improvements to compliance on patient safety alerts, more still needs to be done to achieve full compliance.
"We continue to monitor this data across health boards and have set up a group to look at particular areas of concern. We have made it clear we expect all organisations to make further improvements in the interests of patient safety and quality of services."