Drugs to treat the central nervous system - including painkillers - cost the NHS in Wales more than any other type of drug last year.
Parents of Welsh youngsters with cerebral palsy say their children are being denied a potentially live-changing operation.
As the NHS enters its 66th year, we've been looking at the pressures the service is under and hearing from those who rely on it.
The manager of the Welsh Ambulance Service call centre on the night Joyce Pring rang four times for an ambulance is now giving evidence.
Jill Plemming said the delay in reaching Mrs Pring's husband would not have bumped the 74-year-old up the queue for response, despite the delay being a significant factor in his chance for survival.
Following Mr Pring's death, Jill Plemming conducted an investigation to see if the call handlers treated Mrs Pring correctly. She found there were minor errors, but overall each call complied with the Welsh Ambulance Service's protocols.
She told the inquest each call made by an individual like Mrs Pring is treated in isolation by a call handler.
Coroner John Gittins asked her: "So how can the call handlers assess a deteriorating condition?"
Ms Plemming: "They can't. Each call is being treated in isolation because they can't be influenced by previous calls."
She said each call handler was required to go through the same script, which was why Mrs Pring had to answer the same questions four times during her four calls.
She tells the inquest there is a target response time of eight minutes for an emergency like Mr Pring's condition, which was classified a 'code red 2' emergency for his wife's first three calls.
When Mrs Pring called to say her husband had died, it was elevated to a 'code red 1' emergency, which has the same target response time of eight minutes.
Yesterday Mrs Pring told the court she believed the final call handler showed "a total lack of compassion" when she rang to report her husband had died.
Ms Plemming said today that the call handler was found to have "a professional tone and showed compassion for the caller's feelings."
The second day of Fred Pring's inquest at Ruthin has started with evidence heard from a forensic pathologist.
Mr Pring died at his home in Mynydd Isa, Flintshire, in March last year, after waiting for an ambulance.
Dr Brian Rogers undertook an autopsy following Mr Pring's death. He concludes the former gardener experienced significant congestive heart failure and the chest pains he complained about whilst waiting for an ambulance would have been similar to angina.
Dr Rogers added that Mr Pring was clearly a very ill man.
Asked whether or not Mr Pring would had survived if the ambulance had got there sooner, he replied: "I find it impossible to say, though I think it's unlikely."
The inquest into the death of 74-year-old Fred Pring, who died after waiting 50 minutes for an ambulance, has been adjourned until tomorrow.
A cardiologist has told the inquest into Fred Pring's death that if an ambulance had attended quicker, "more likely than not he would have survived".
Dr Raj Thaman said he would expect an ambulance to get to a patient within six minutes of an emergency call and this would have been enough time to save his life, "in all probability".
Coroner John Gittins asked him: "If an ambulance had responded after the first call, within the expected time frame, then it's more than likely that a patient like Mr Pring would have survived?"
"Yes," replied Dr Thaman. "The faster the response, the greater the chance of survival."
Dr Thaman said that, in his opinion, the ambulance service had a 10-minute opportunity to save Mr Pring.
He added that Mr Pring's condition appeared to deteriorate very quickly and by the time his wife made the second phone call for an ambulance it was probably already too late to save him.
The inquest into the death of Fred Pring has resumed after a short break.
We're now hearing from PC Ashton, the officer called to Mrs Pring's home after her husband had died.
He tells the inquest that Clwyd Richards, the paramedic, told the officer he felt "embarrassed" they hadn't attended earlier because there was a chance they could have saved Mr Pring's life.
Mr Richards told the coroner he doesn't recall saying those exact words.
The widow of a man who died after waiting for an ambulance for nearly an hour after developing chest pains hopes an inquest into his death will address her unanswered questions.
Describing the events leading up to her husband Fred's death, Joyce Pring told ITV News' Debi Edward: "He just couldn't take anymore, he just said 'I'm going' and that was it...it was too late."
She added: "That is probably the worst thing for me really, that his last hour was very painful for him and I wouldn't have wished that for him".
Welsh Ambulance Service has previously apologised for not sending an ambulance in a "more timely manner" due to a backlog handing over patients at hospital.
Earlier today, a statement from Mrs Pring's solicitors said she believes her husband was "let down by a systemic failure and does not seek to blame any one individual in this case".
We are now hearing evidence from Clwyd Richards, a paramedic who attended to Mr Pring.
Mr Clwyd told the inquest it was "a very busy shift, we were flat out" but that being so busy was not out of the ordinary for them.
He described the process of bringing patients to hospital then waiting with them until a bed is available.
"I've had a four-and-a-half hour wait outside Wrexham Maelor hospital before now," he told the coroner.
Mr Clwyd explained the process of categorising patients during a callout - Red 2 was the initial category Mr Pring was put into, but after Mrs Pring's fourth call he was put in a Red 1 cardiac arrest call - the most serious category.
He and two other ambulances attended after that call, he said.
We've just heard a written statement from the first ambulance to attend the home of Mr Pring after he had died.
Three ambulances arrived in total, minutes after Mrs Pring's fourth call telling the ambulance service it was too late.
The paramedic said when control called them asking them to attend at Mr Pring's address, he and his colleague were on a "non-disturbable meal break" after being on duty non-stop for more than six hours.
He said: "We politely declined because we were on a non-disturbable meal break. We were fatigued and we needed a break."
Eventually they interrupted their break to attend to Mr Pring.
The paramedics described "significant delays" at Wrexham Maelor Hospital before receiving this particular call, because A&E were very busy that night.
There was a wait to transfer a patient from their ambulance to the hospital, the inquest heard.
"When we attended the address, Mrs Pring told us it was too late", the paramedic said in his statement.
Widow Joyce Pring left the room as an inquest was played almost 20 minutes of audio of her four emergency calls to the ambulance services.
When she returned, coroner John Gittins told her it was "perfectly understandable" why she had not wanted to hear them again, because they were so distressing.
Mr Gittins said: "The second call is particularly harrowing because we can quite clearly hear the pain [Fred] is in."
Mrs Pring told the inquest another aspect of having to make so many phone calls that night was that it took away from time she could have been spending with her husband - in what turned out to be his final minutes of life. The couple had been married for 38 years.
Joyce Pring has told an inquest that the female operator on her fourth and final call to the emergency services showed "a total lack of compassion" when she reported her husband had just died.
"She told me to get him on the floor and unblock his airways," Mrs Pring said.
"I told her it was too late because he'd already died. Within a few minutes three ambulances turned up, all too late to do anything."
Coroner John Gittins asked Mrs Pring if she hoped sharing her experience would prevent others going through a similar ordeal.
She replied: "I would like that, but I think others will go through what I have. I don't think much is going to change."