The Welsh Government will today announce when legislation on a 'soft' opt-out system for organ donation will come into effect here.
It means everyone will be presumed a potential organ donor - unless they have specifically stated that they wish not to be.
The Human Transplantation (Wales) Bill hasn't been welcomed by everyone, but ministers hope it will increase the number of organs available for transplants.
The Bill was passed by the National Assembly on July 2, with 43 AMs voting for, eight against and two abstaining.
It makes Wales the first UK nation to introduce such a system.
The Bill will also receive Royal Assent during a special ceremony today.
A two year publicity campaign is to follow a change in the law in Wales on organ donation. The Assembly has agreed that people should follow an opt-out policy rather than an opt-in one.
Campaigners have hailed an historic vote in the Assembly last night. AM's voted to change the organ donation law in Wales meaning in future people will have to opt out. But Dan Boucher of the Christian social policy charity CARE says the law is not welcomed by everyone.
A historic day for #organdonation in Wales: Assembly votes in favour of progressive Human Transplantation (Wales) Bill.
AMs have passed the Organ Donation Bill Wales. There were 43 AMs who voted for the bill, eight voted against and there were two abstentions. From now on, patients will have to opt out of being an organ donor.
Campaigners say a change in the law will lead to a 25% increase in organs which are available for transplant. For the hundreds of people in Wales who are in desperate need of a donation, that will give them massive hope as our Correspondent Joanna Simpson has been finding out.
A vote will take place later to change the law on organ donation. If the legislation is passed Wales will become the only part of the UK where doctors will presume consent's been given. Health Minister Nick Drakeford says it will save lives.
A radical shake-up of the law on organ donations is to be voted on today by Welsh Assembly politicians.
If they back the bill, Wales will become the first country in the UK to have an "opt-out" system. This would mean that in the event of death, a person's organs could be used without giving consent.
Ministers in Cardiff Bay say there is a desperate need to drive up transplantation rates - with 226 people in Wales waiting for a transplant - and they hope the new system will drive up rates by around a quarter.
If passed the presumed consent system could come into force by 2015.
The Welsh Government says it would have to spend at least £8m on publicising the changes.
It would apply to over-18s who die in Wales if they have lived in Wales for more than 12 months.
Organs available would be the same as the "opt-in" method - including kidneys, heart, liver, lungs and pancreas .
Organs would not only go to donor patients in Wales. They could go anywhere in the UK.
The health minister says organs would not be taken unless a family member is present.
Religious leaders describe it as a "conscription" system which could distress bereaved families.
Some critics say evidence from other countries with the system shows it has not produced any real changes.
The matter will be debated in the Assembly at around 4pm. It is scheduled to last around two hours before a vote is taken.
Click here for the government's Human Transplantation Bill for Wales.
Kidney Wales Foundation has been campaigning for a new organ donation law for five years. The charity's chief executive Roy J Thomas told ITV News that the Human Transplantation Bill was a "progressive piece of legislation" that could bring a new culture of organ donation to Wales.
Dr Barry Morgan, Archbishop of Wales, told ITV News that he is in favour of organ donation, but feels the Human Transplantation Bill needs amending to take relatives' feelings into account.