This evening sees the West Wales derby in the RaboDirect PRO12. Our Sports Correspondent Richard Morgan looks ahead to the big game.
Reigning champions the Ospreys were beaten last night, but the Dragons got off to a flying start with a bonus-point win.
Ospreys go down in pre-season friendly
Wales's players return to club rugby this weekend following the autumn internationals. All four regions are in European action - the Scarlets are at home to Exeter, while the Blues take on Montpellier in the Heineken Cup.
The Dragons are against Mogliano in the Amlin Challenge Cup, and the Ospreys have a tough challenge against Toulouse in the Heineken Cup.
Ospreys coach Jonathan Humphreys says the "odds will be stacked" against them due to many players being injured on international duty.
Wales' injury worries have been worsened with the news that second row Ian Evans is a doubt for the start of the Six Nations. His club, the Ospreys, say he will be out of action for up to eight weeks for surgery on an ongoing knee problem.
The Ospreys say: 'Ian has been troubled by an ongoing problem with his right knee since being unable to complete the Samoa game. Investigations and consultations with specialists have resulted in him undergoing a keyhole procedure, as a result of which he will be sidelined for six to eight weeks.'
The Ospreys have signed former All Black Campbell Johnstone until the end of the season.
The team says the move provides "much needed cover for existing tight-heads Aaron Jarvis, Adam Jones and Joe Rees who are all ruled out with injury. "
The 32-year-old from Waipukurau will start at the club in time for back-to-back Heineken Cup clashes.
Johnstone's arrival comes just days after the return of Cai Griffiths on loan from London Irish.
– Andy Lloyd, Rugby Operations Manager at the region
The arrival of Campbell and Cai gives us some much needed options at tight-head given the injuries we've suffered and the ongoing commitments we have to the national set-up at senior and age-grade level.
Ospreys back row, Ryan Jones, has returned home from the Wales national squad training camp in Spala on Wednesday morning so he can undergo scans on an irritable shoulder.
Jones was part of the 35-man squad preparing for the Dove Men Series against Argentina, Samoa, New Zealand and Australia which starts on November 10 but his shoulder problem has meant he's had to return home.
The Welsh Rugby Union says Jones remains a full member of the squad and hope to release further details once his shoulder has been examined.
The Ospreys picked up their first home win of the PRO12 season on Saturday night, beating Munster at the Liberty Stadium.
Full-back Richard Fussell and hooker Richard Hibbard crossed the line, and the home side were also awarded a penalty try. Fly-half Dan Biggar added 15 points with the boot.
The visitors were restricted to five penalties, as the Ospreys kept up their momentum after last week's win over the Scarlets.
The Scarlets themselves are heading in the opposite direction, losing their second game in succession after such a strong start to the season.
They raced into a 20-5 lead at Treviso, after two tries from winger Andy Fenby and 10 points from Rhys Priestland. The Italian hosts struck back with two tries, before fly-half Alberto Di Bernardo pinched victory with a long-range penalty in the dying seconds.
Shane Williams sings the praises of his teammates, and coach Steve Tandy - who only took over at the Ospreys in February - after they claimed the PRO12 title. The 35-year-old winger's two late tries helped the Welsh side to a dramatic victory at the home of the European champions.
Ospreys hero Ryan Jones, departing winger - and Irishman - Tommy Bowe, and even domestic rival, Cardiff Blues flanker and Wales captain Sam Warburton, have paid tribute to the PRO12 champions' achievement on Twitter.
What a game! What a win! Well done Ospreys!!!From @TommyBowe14 on Twitter:
OSPREYS!!! Superb game well done boys!!!From @samwarburton_ on Twitter: