Wales coach Warren Gatland will lead out an international side for the 100th time tonight
Cardiff Blues centre Cory Allen makes his Wales debut against Argentina on Saturday while prop Gethin Jenkins wins his 100th cap.
The 25-year-old requires surgery for a chest injury after rupturing a muscle.
Captain Sam Warburton has challenged his team ahead of their clash with Australia. He says the squad will need to raise their game if they are to secure a win against the Wallabies.
Wales have failed to boast a victory since 2008, losing in eight consecutive tests.
The return of Alex Cuthbert puts the Welsh squad in a confident position to play a level game. Elsewhere, flanker Dan Lydiate sits on the back row.
Warburton says the recent lions success will not have any bearing on this game and Wales must strive to end the southern hemisphere jinx.
Newport Gwent Dragons lost 14-18 to Munster at Rodney Parade. The home side led at half time, thanks to two penalties from Jason Tovey. They extended their lead early in the second half, courtesy of a try by Matthew Pewtner,
Ian Keatley was the standout performer for the visitors, kicking all 18 points for the Irish region.
The Ospreys lost 16-28 at home to Glasgow this evening, after leading with just over ten minutes to go.
Two late tries from DTH van der Merwe and Ryan Wilson denied the Welsh side the win and even a losing bonus point.
Alex Cuthbert told ITV News he's been working hard with physiotherapists to recover from injury, but it was 50/50 how he would respond to treatment. He says the Australia game will 'lift the boys' and hopefully they'll come away with a win.
It's great to have Alex and Scott available and they bring a lot of experience into the back line. Alex and the medical teams have worked really hard to ensure he is ready for this weekend and it's great to be able to bring him back into the side.
We though Owen (Williams) performed well in the centre against Tonga and he gets another opportunity on Saturday.
There is a lot of experience in the pack for what is going to be a very physical game.
– Warren Gatland, Wales Head Coach
We are looking to finish the series off well, the last three games against Australia have gone right down to the wire and I don't expect anything different this weekend.
Wales Head Coach Warren Gatland has announced his squad to face Australia early. Alex Cuthbert and Scott Williams have both returned from injury to join the starting line up for Saturday's final match in the autumn series. This will be Cuthbert's first appearance for Wales in the autumn series.
Leigh Halfpenny, Alex Cuthbert, Owen Williams, Scott Williams, George North, Dan Biggar, Mike Phillips, Gethin Jenkins, Richard Hibbard, Rhodri Jones, Alun Wyn Jones, Ian Evans, Dan Lydiate, Sam Warburton, Toby Faletau.
Ken Owens, Ryan Bevington, Samson Lee, Ryan Jones, Justin Tipuric, Rhodri Williams, Rhys Priestland, Liam Williams.
Wales could recall Lions winger Alex Cuthbert for the final autumn international against Australia. Cuthbert had been expected to miss the whole of the autumn series after suffering an ankle injury while playing for the Cardiff Blues.
The 23 year-old is set to be assessed by the Wales doctors during training this week after getting the call up along with Ospreys second row James King.
Warren Gatland says he's "confident" ahead of Wales' final autumn series clash against Australia next Saturday.
His side have now won two autumn internationals on the bounce - after having gone four years without one - but failed to score a single point in the second half of yesterday's 17-7 win against Tonga.
"I think we've got to be confident," he said.
"We've got to look forward to it. We were very disappointed with the first game (against South Africa).
"We were behind and got back into it, showed some character in terms of dealing with injuries and I know in the past we wouldn't have been able to do that.
"If we can win next week and finish with three from four I think that would be a satisfactory autumn."
Warren Gatland says last night's Autumn International against Tonga was "a little bit frustrating", as he watched his side score two first half tries on their way to 17-7 win, before failing to score in the second half.
"It's a win. It was a little bit frustrating. Tonga tried to slow the game down and frustrate us and they pretty much did a good job of it," he said.
"It was a good start, a positive start, I think the ambition was there. We got across the try line, I think, four times. Unfortunately we weren't able to convert those close chances.
"We probably weren't quite as clinical as we needed to be, but for a lot of those players it was their first time together and I can't fault the effort in terms of the ambition.
"We're not that pleased with the performance but it's a win and maybe in the past those are the games we might have succumbed."