Cardiff and Vale University Health Board is to carry out consultations with management and unions over staff reorganisation which could lead to redundancies.
The service change plans potentially affect around 385 employees says the health board.
“Many of these plans involve redesigning a number of services to deliver the same, or better, care in a different way, and in a more cost effective way. This includes reshaping the UHB’s workforce, in line with what has been proposed," says the board's Chief Executive, Adam Cairns.
The health board employs 14,500 staff and says redundancies will be a "last resort" and staff who need to change roles will be offered training to assume new responsibilities.
As Diabetes Awareness Week begins today, a 'diabetes vaccine' is undergoing clinical trials at the University Hospital of Wales, Cardiff, in the hope that it might eventually lead to a cure.
Scientists are working to develop a vaccine to slow or halt the autoimmune process that destroys the insulin-making cells in Type 1 diabetes.
More than 160,000 people in Wales have been diagnosed with diabetes - nearly five per cent of the population.
It is estimated that 66,000 more could have the condition but have not yet been diagnosed.
Cynon Valley MP Ann Clwyd has spoken in a Commons debate about the care her late husband received in hospital.
Owen Roberts died at the University Hospital of Wales, Cardiff, in October 2012.
Ms Clwyd read from a copy of a newly-published confidential 117 page report into his death, which revealed he spent 27 hours on a trolley in A&E with minimal food and water.
All of those who were at the University Hospital of Wales after being injured in a series of collisions in Cardiff just over a week ago have now been discharged.
The alleged hit-and-run collisions took place in several locations to the west of Cardiff, including Grand Avenue, Cowbridge Road West and the Leckwith Retail Park on October 19.
31-year-old Karina Menzies died as a result of the incident.
13 other people were injured including at least seven children.
A 31-year-old man remains in police custody charged with murder, 13 counts of attempted murder, four counts of actual bodily harm and one of dangerous driving. He will reappear in court on 28th January.
A suspension order against the midwife heavily criticised for her role at the birth of baby Noah Tyler, who died after suffering brain damage when he was born, will continue. Julie Richards' suspension will be reviewed in three months, a malpractice hearing ruled this morning.
Yesterday, Cardiff coroner Mary Hassell said Ms Richards blamed "gross failure" to provide adequate care for Noah's difficult birth, and subsequent death when he was just 10 months old. Earlier in the inquest proceedings, Ms Richards admitted making "catastrophic mistakes" at the birth.
Hywel Tyler, the father of ten-month-old Noah, who died after suffering brain damage at birth, says that the verdict at his inquest was consistent with what he and his wife Colleen believed all along.
They have recently had a new baby boy, and he says his positive experience on the University Hospital of Wales' maternity ward confirms that "there's a good unit there."
The coroner at the inquest into the death of baby Noah Tyler has recorded a narrative verdict. He suffered irreversible brain damage during his birth at the University Hospital of Wales, in Cardiff, in February 2011, and died ten months later.
The coroner at Cardiff Coroner's Court has retired to consider her verdict on the death of Noah Tyler, a 10-month-old baby who died in December after complications during his birth.