Betsi Cadwaladr University Health Board agreed proposals for 'significant' changes to be made to healthcare services in several areas.
In Blaenau Ffestiniog, Ffestiniog Memorial Hospital will be developed as a base for improved community services, primary care services will be expanded and the X-ray and minor injury units will be closed, although GPs will continue to provide minor injury services.
Inpatient beds and inpatient care will close at Ysbyty Alltwen.
In North Denbighshire, Prestatyn Community Hospital will close, but a new hospital will be developed at the Royal Alexandra Hospital site in Rhyl, subject to Welsh Government approval.
In Llangollen, the minor injury unit will close, along with inpatient beds and provision of inpatient care at Chirk. A primary care resource centre will be developed at the River Lodge site, subject to Welsh Government approval.
In Flint, inpatient beds and inpatient care will close at Holywell Hospital, as well as the minor injury units, but a primary care resource centre will be developed following approval by the Welsh Government.