Gethin Jenkins will miss Wales' RBS 6 Nations clash against Scotland at Murrayfield on Saturday.
The Toulon prop, who has won 97 caps, suffered a calf muscle injury during the 26-9 victory over Italy in Rome 10 days ago and is replaced by Bath forward Paul James.
Two other changes from that game see flanker Sam Warburton - last season's Grand Slam captain - return to the starting line-up instead of Justin Tipuric, while lock Alun-Wyn Jones replaces Andrew Coombs.
But even though Warburton has been recalled - he suffered a shoulder injury earlier in the championship - his back-row colleague Ryan Jones remains as skipper.
Wales' interim head coach Rob Howley retains the same back division for a fourth successive game, but three changes on the bench from Rome see Cardiff Blues prop Scott Andrews come in for James, with Coombs and Tipuric swapping places with Jones and Warburton respectively.
More top news
Rain and drizzle will clear eastern counties this evening. Remaining mild with breaks in the cloud by dawn.
A leading vet charity warns that you could end up with a stressed, lonely or even aggressive pet if you don't care for it properly.
From pensioners to first-time buyers to public sector workers, a rundown of how today's Autumn Statement and Spending Review affect you.