Gethin Jenkins will miss Wales' RBS 6 Nations clash against Scotland at Murrayfield on Saturday.
The Toulon prop, who has won 97 caps, suffered a calf muscle injury during the 26-9 victory over Italy in Rome 10 days ago and is replaced by Bath forward Paul James.
Two other changes from that game see flanker Sam Warburton - last season's Grand Slam captain - return to the starting line-up instead of Justin Tipuric, while lock Alun-Wyn Jones replaces Andrew Coombs.
But even though Warburton has been recalled - he suffered a shoulder injury earlier in the championship - his back-row colleague Ryan Jones remains as skipper.
Wales' interim head coach Rob Howley retains the same back division for a fourth successive game, but three changes on the bench from Rome see Cardiff Blues prop Scott Andrews come in for James, with Coombs and Tipuric swapping places with Jones and Warburton respectively.
More top news
Chelsea Manning will be freed in five months after President Obama reduced her remaining prison sentence for leaking government documents.
Staff working in sterilisation and disinfection units at Abertawe Bro Morgannwg University Health Board hospitals will go on strike over pay
Carwyn Jones has told AMs about a phone call with Theresa May before her Brexit speech. He also said he fears for Welsh ports post-Brexit.