South Wales Police says the A465 is closed between Aberdulais and Resolven, after a serious crash.
Diversions are in place via the B4242.
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Friday night is not looking the brightest, and I am sorry to say there is worse to come for the start of the weekend!
Wales' Women face their first clash of the Six Nations against defending champions Ireland Saturday at Donnybrook
The body of John Sabine was found behind flats on a council estate in Beddau, near Pontypridd, last November.