A 45-year-old man from Maesteg died in a collision on the A465 at Resolven near Neath, police say.
A white Renault articulated lorry vehicle crossed the central reservation and collided with a white Citroen van travelling on the opposite carriageway at around 3.40pm on Thursday.
The driver of the van was pronounced dead at the scene, while the van's passenger and lorry driver were taken to Morriston Hospital for treatment.
South Wales Police are appealing for anyone who witnessed the collision to contact them.
More top news
Nicky Stevens, the only Welsh national to win Eurovision, marked 60 years of the competition at a special event held in London last night.
Any early brightness will be short lived as cloud becomes widespread and outbreaks of rain heavy during the afternoon. Lighter winds.
Pet owners are being advised about the dangers of chocolate this Easter as vets warn it is poisonous to dogs.