A 45-year-old man from Maesteg died in a collision on the A465 at Resolven near Neath, police say.
A white Renault articulated lorry vehicle crossed the central reservation and collided with a white Citroen van travelling on the opposite carriageway at around 3.40pm on Thursday.
The driver of the van was pronounced dead at the scene, while the van's passenger and lorry driver were taken to Morriston Hospital for treatment.
South Wales Police are appealing for anyone who witnessed the collision to contact them.
More top news
The whale is made of bags, bottles and other single-use plastics pulled from the ocean, beach and recycling plants.
Skies will cloud over with outbreaks of rain and drizzle.
An article in The Sunday Times found Isis used a network of companies operating out of an office in Cardiff to finance terror plots.