Cardiff and Vale University Health Board is to carry out consultations with management and unions over staff reorganisation which could lead to redundancies.
The service change plans potentially affect around 385 employees says the health board.
“Many of these plans involve redesigning a number of services to deliver the same, or better, care in a different way, and in a more cost effective way. This includes reshaping the UHB’s workforce, in line with what has been proposed," says the board's Chief Executive, Adam Cairns.
The health board employs 14,500 staff and says redundancies will be a "last resort" and staff who need to change roles will be offered training to assume new responsibilities.