Both sides are yet to score as the Bluebirds host Manchester City in their first home Premier League game of the season.
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The peer will attack Prime Minister Theresa May for failing to represent the 48% who voted in favour of Remain.
Paul Flynn, MP for Newport West, will open the debate in Westminster Hall.
It will represent another boost to the region, after the announcement Deca Sealand was chosen for a repair hub for defence aircraft.