Two hundred and thirty one jobs are under threat tonight at Dairy Company, First Milk, just outside Wrexham.
The company told staff in Maelor that they plan to close the factory in 2014.
Welsh Secretary David Jones said: "This is a sobering reminder of the challenges the Welsh economy still faces.
"We need to ensure we maintain close relations with businesses on the ground in Wales, focus on retaining and creating jobs, and attracting new business opportunities across the country."
The company has been asked for a statement.
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Breezy overnight. It will become fairly cloudy as the night progresses.
It should turn cloudier through the early hours with some patchy drizzle and some hill fog too.
It will be a breezy day with variable amounts of cloud and some bright or sunny spells.