Two hundred and thirty one jobs are under threat tonight at Dairy Company, First Milk, just outside Wrexham.
The company told staff in Maelor that they plan to close the factory in 2014.
Welsh Secretary David Jones said: "This is a sobering reminder of the challenges the Welsh economy still faces.
"We need to ensure we maintain close relations with businesses on the ground in Wales, focus on retaining and creating jobs, and attracting new business opportunities across the country."
The company has been asked for a statement.
More top news
A cat rescue charity in Ebbw Vale is worried it won't be able to find homes for its 70 cats.
A teenager is calling on the Welsh Government to lower the age of cervical screening for women - after she was diagnosed with cancer.
Over 100,000 fans descend on Cardiff next week for One Direction concerts leading to a "Full Closure" of the city centre on both nights.