Two hundred and thirty one jobs are under threat tonight at Dairy Company, First Milk, just outside Wrexham.
The company told staff in Maelor that they plan to close the factory in 2014.
Welsh Secretary David Jones said: "This is a sobering reminder of the challenges the Welsh economy still faces.
"We need to ensure we maintain close relations with businesses on the ground in Wales, focus on retaining and creating jobs, and attracting new business opportunities across the country."
The company has been asked for a statement.
More top news
The heaviest of the rain will ease overnight. Remaining mild but breezy around coastal areas.
Every time you give blood, you save a life. And for 70 years, more than 10 million units of blood have been donated in Wales.
A prosecution witness claimed he saw Mr Anglesea visit the house of convicted paedophile Gary Cooke.