Two hundred and thirty one jobs are under threat tonight at Dairy Company, First Milk, just outside Wrexham.
The company told staff in Maelor that they plan to close the factory in 2014.
Welsh Secretary David Jones said: "This is a sobering reminder of the challenges the Welsh economy still faces.
"We need to ensure we maintain close relations with businesses on the ground in Wales, focus on retaining and creating jobs, and attracting new business opportunities across the country."
The company has been asked for a statement.
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A cloudy picture to start with but also some sunny spells around. Feeling rather humid out there.
This evening will stay cloudy but dry and the night will be mild and humid across the country.
An ITV News investigation has revealed the worrying scale of contamination and pollution in our rivers from farm waste.