James Corden plays Paul Potts in One Chance, a film about about the Port Talbot opera singer's life.
Corden told ITV News "it's such an uplifting, moving film", which shows how Potts fought "through so much adversity" and realised his dreams, because he refused to give up on them.
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The peer will attack Prime Minister Theresa May for failing to represent the 48% who voted in favour of Remain.
Paul Flynn, MP for Newport West, will open the debate in Westminster Hall.
It will represent another boost to the region, after the announcement Deca Sealand was chosen for a repair hub for defence aircraft.