The NSPCC say the number of calls made to the their helpline about neglect is higher in Wales than anywhere else in the UK.
Every month, the helpline assists approximately 35 children in Wales.
In the 12 months to March 2013, the charity say they dealt with more than 450 cases, which had to be referred to social services or police for further investigation.
Many of the children involved were under six years old, with concerns ranging from home living conditions to poor parenting and emotional neglect.
Des Mannion, NSPCC national head of service for Wales, said:
"The NSPCC's study, Child Cruelty in the UK 2011, found that around one in ten 11-17-year-olds have experienced neglect at some time in their lives.
But now more people than ever are contacting the NSPCC about child neglect. Some of this will be down to the public being more willing to speak out - and this can only be a positive thing - but there is clearly a worrying trend, not just in our figures, but from a range of agencies and bodies."