The mother of a girl who attends Morriston Comprehensive School told ITV News that younger children may be intimidated having to use unisex toilets.
Emma Rees, who has a 13-year-old daughter, at the school says she's told her not to use the toilets. She says young girls need their privacy in toilets.
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David and Angela Southwood, from Newport, say they plan to live in a caravan over the border after learning of the decision.