The Welsh Government has announced that David Sissling, the Chief Executive of NHS Wales, is to move to a new role in the East Midlands.
He will leave his current post in March, and will take up a 'a senior role' in the NHS close to his family home.
“This has been a very difficult decision for me and not without mixed feelings" he said.
"There is never a perfect time to leave any role, particularly in the health service which faces continual challenge and change".
More top news
Letters written by Jackie Kennedy to Welshman David Ormsby-Gore go to auction at Bonhams today. They're expected to sell for up to £150,000.
The group, which is being set up by Labour to examine how best to redistribute powers across the UK, will meet for the first time.
Plaid Cymru demands an urgent Senedd debate and Labour launches a consultation on the UK's future as the process of leaving the EU begins.