The Welsh Government has announced that David Sissling, the Chief Executive of NHS Wales, is to move to a new role in the East Midlands.
He will leave his current post in March, and will take up a 'a senior role' in the NHS close to his family home.
“This has been a very difficult decision for me and not without mixed feelings" he said.
"There is never a perfect time to leave any role, particularly in the health service which faces continual challenge and change".
More top news
Report into emergency units at Cardiff and Vale Health Board finds a culture of bullying, harassment and inappropriate behaviour
After a fine evening with late sunshine, largely dry overnight before cloud thickens later with the threat of showers across Wales.
Staff from Nevill Hall Hospital have been recognised for helping to stop a vicious attack