Warren Gatland said Wales' performance against Ireland on Saturday was "very disappointing", adding that the difference between the two sides was Ireland's domination up front.
Wales' 26-3 defeat in Dublin on Saturday was their first loss on the road in the Six Nations since they were beaten 28-9 in Paris three years.
It means the defending champions face an uphill struggle if they are to achieve a record three Six Nations titles in a row.
Welsh hopes of achieving an unprecedented Six Nations title hat-trick took a beating in Dublin, as Ireland romped to a 26-3 victory.
Warren Gatland's Wales team will take on an Ireland side, who prop Adam Jones says will be "revved up" come kick-off.
With a squad that has now seen success in the Six Nations and Lions tour, Howley believes there is no game they can't deliver in.