Wales centre Scott Williams has been released from the Six Nations squad after suffering an injury in the game against Ireland.
Williams left the field 17 minutes into Saturday's game at the Aviva Stadium in Dublin after coming off worst tackling Brian O'Driscoll. The WRU says Williams has injured his right shoulder and will need surgical intervention.
Welsh hopes of achieving an unprecedented Six Nations title hat-trick took a beating in Dublin, as Ireland romped to a 26-3 victory.
Warren Gatland's Wales team will take on an Ireland side, who prop Adam Jones says will be "revved up" come kick-off.
With a squad that has now seen success in the Six Nations and Lions tour, Howley believes there is no game they can't deliver in.