Wales head coach Warren Gatland has made three changes to the team which lost 26-3 to Ireland.
Sam Warburton captains Wales once again.
Wales team: Leigh Halfpenny; Alex Cuthbert, George North, Jamie Roberts, Liam Williams; Rhys Priestland, Rhys Webb; Gethin Jenkins, Richard Hibbard, Adam Jones; Luke Charteris, Alun Wyn Jones; Dan Lydiate, Sam Warburton (c), Taulupe Faletau.
Wales replacements: Ken Owens, Paul James, Rhodri Jones, Jake Ball, Justin Tipuric; Mike Phillips, Dan Biggar, James Hook.
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The former Wigan and Great Britain rugby league star previously enjoyed a successful club coaching career with Wasps.