Wales lock Luke Charteris has been forced out of Sunday's clash with England.
In his place is Scarlets forward Jake Ball for his second Six Nations start.
He comes into a side who have recovered well from their defeat to Ireland earlier in the championship, a turn around which means that with two games left to play Wales' hopes of a third consecutive Six Nations title are very much alive.
With their Six Nations title hopes now all but gone, Wales head coach Warren Gatland admits the countdown to next year's World Cup is on.
We take a look back through the archive to find the most iconic moments from Six Nations clashes between Wales and England.