Leigh Halfpenny, who dislocated his right shoulder against England on Sunday, will undergo surgery tomorrow.
He is expected to be out for up to four months, the WRU says.
Rhys Webb has now been released from the National Squad following his ankle injury, and will be assessed by a medical team at the Ospreys.
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Traffic on the M4 from Coryton to Cardiff is at a standstill following a multiple vehicle crash.