Leigh Halfpenny, who dislocated his right shoulder against England on Sunday, will undergo surgery tomorrow.
He is expected to be out for up to four months, the WRU says.
Rhys Webb has now been released from the National Squad following his ankle injury, and will be assessed by a medical team at the Ospreys.
More top news
The Met Office has issued a yellow warning to be aware of heavy rain overnight
An ITV News investigation has revealed a twenty-fold increase in police incidents involving legal highs in Wales in just two years.
The Met Office has issued severe weather warnings for much of Wales for tonight, believe it or not!