Leigh Halfpenny, who dislocated his right shoulder against England on Sunday, will undergo surgery tomorrow.
He is expected to be out for up to four months, the WRU says.
Rhys Webb has now been released from the National Squad following his ankle injury, and will be assessed by a medical team at the Ospreys.
More top news
Swansea City failed to capitalise on last weekend's dramatic win over Crystal Palace, as they fell to a heavy 5-0 defeat away at Tottenham.
Post Office workers and managers have held a third strike in a long-running dispute over job losses and pensions.
After a cloudy start it will be a dry day today. The cloud will break up this afternoon, with some bright or sunny spells developing