The countdown is on to Text Santa, our big, star-studded charity fundraiser, on ITV1 tomorrow night.
It aims to raise money for six chosen charities, including Anthony Nolan that helps people with blood cancer.
One of those it helps is 9 year old Issy Miller from Dorset. She will spend this Christmas in hospital, isolated from the rest of the world, after under-going a life-saving bone marrow transplant.
She was diagnosed with Leukaemia in September but working with Anthony Nolan, Bristol Children's Hospital quickly found a donor match to go ahead with the procedure.
Richard Payne has followed Issy's story before and after the transplant:
For more information on Anthony Nolan, visit their website here.
And if you'd like to know more about Text Santa go here.
Marie Curie Cancer Care is one of six charities to benefit from Text Santa - ITV's Christmas fundraiser. Marie Curie nurses help care for terminally ill patients in their homes, and offer emotional support to families. Catherine Le Roy is one such nurse.
For more information on Marie Curie Cancer Care click here
11 year old Ethan Jones has a very rare condition called Ring Chromosone 14. There are just 40 to 60 cases worldwide. It causes epilepsy, respiratory problems and global delay. It means Ethan needs care around the clock.
Children's Hospice South West helps families like Ethan's. Its three hospices in the region offer care for children who have illnesses which mean they wil die before reaching adulthood. It is supported by the charity, Together for Short Lives.
For more information on Together for Short Lives click here