Tony Nicklinson from Melksham in Wiltshire has lost his high court battle to end his life when he chooses with the help of a doctor.
The judges unanimously agreed that "voluntary euthanasia is murder, however understandable the motives may be."
Mr Nicklinson has suffered from 'locked-in' syndrome since he had a stroke in 2005. A second sufferer of the syndrome, who cannot be identified, has also lost his legal challenge.
Jane Nicklinson has welcomed the Anna Soubry's willingness to "stick her neck out" on the issue of assisted suicide law.
Tony Nicklinson from Melksham in Wiltshire has lost his right-to-die appeal