Nigel Davies' first game as Gloucester head coach ended in a home defeat to Northampton.
George Pisi scored two tries for the visitors, while nine points came from the boot of former Kingsholm favourite Ryan Lamb.
Freddie Burns kicked 14 points for the Cherry and Whites.
Yeovil Town won for a club record 8th time in a row. Bristol Rovers also won, Cheltenham drew and Bristol City lost in the Severnside derby.
There were wins today for both Bristol clubs and Yeovil Town. Swindon Town could only draw and Cheltenham Town slipped to defeat.
Bath have beaten West Country rivals Gloucester 32 - 5 in the LV= Cup.