Anchor Road, Canons Road, Canons Way, Lower College Street, Bridge Valley Road, the Portway, some roads around the Cumberland Basin System and others will be closed early morning until mid-afternoon.
The race starts at 09:30 from Anchor Road, Harbourside.
More top news
The rare 1901 edition of The Tale of Peter Rabbit will go under the hammer to mark the 150th anniversary of the author's birth.
Just exactly what is Hinkley Point C - and why do we need it?
It's not feeling too summery is it? Another wet, cloudy and dreary start for the South West. Kate Haskell has the forecast.