A five-year-old girl from Exeter who had a very rare type of brain tumour has died.
Billie Bainbridge was diagnosed with diffuse intrinsic pontine glioma - an inoperable brain stem cancer - last summer.
Her condition deteriorated rapidly after a brain scan on 3 May showed significant tumour growth. In the last week, she was having difficulty with breathing and was confined to bed.
A statement on the site said that Billied died "peacefully at home" on Friday afternoon with her parents Sam and Terri beside her and her family nearby, including her three-year-old brother Joe.
Over the past year, Billie's family had tried to raise £200,000 that would have enabled Billie to travel to America for life saving treatment. Comedian Peter Kay also tried to help by staging two gigs with the proceeds going towards Billie.
Donations were being made to the Billie's own fundraising website, Billie Butterfly Fund.
Billie's mother Terri has aggressive breast cancer and was undergoing chemotherapy when Billie first showed signs she was not well.
Only about 40 children in the UK are diagnosed with this form of brain tumour each year. The survival rates are extremely poor with many children not surviving more than eighteen months. Radiotherapy can be used in an attempt to shrink the tumour and reduce symptoms, but frequently the tumour starts growing again within six to nine months, this time more aggressively.
To read more about Billie's story and to learn about this form of brain tumour, click here.
We spoke to Billie and her family in November 2011. Watch our report: