The high-value burglary took place at the Spot nightclub in Godwin Court in Swindon at around 3.15am on Saturday 8th July 2012.
A large amount of cash was taken from the club and police believe the suspect then left the building via the alleyway by the Spot Bar leading to Barclays Bank.
Police are want to hear from anyone who was in the area at the time who saw or heard anything suspicious including people entering or leaving the building or loitering around outside.
The arrests have been made during the opening 48 hours of Avon and Somerset Police's latest Operation Relentless.
The operation is targeting those who are involved in burglary, robbery and car crime across the force's area. These crimes account for more than half of all the crimes recorded in Avon and Somerset.
In Bath an antique carriage clock worth more than £4,000 and antique furniture worth more than £40,000 were among nearly 100 items recovered by police.
Three men have already been arrested on suspicion of burglary and handling stolen goods and have been released on police bail, pending further inquiries. They are among 40 people who have been arrested for suspected offences within the first 48 hours of the operation.
Police officers, police community support officers and special constables are also patrolling across the force area offering members of the public crime prevention and crime reduction advice.
Police have released an efit of a man wanted in connection with a burglary at a home in Hillesley.
The man was seen running from the property when the family returned home at 9.30pm on Monday.
Anyone who recognises the man should call Gloucestershire Police on 101
Police have issued an image of two men they would like to speak to in connection with a burglary in Exeter.
The incident took place at around 5.30pm on Wednesday 4th July at a property in Regents Park.
Two men broke into the garage and attempted to remove bike locks, before leaving the scene empty-handed.
Anyone with information regarding the burglary is asked to contact the Police on 101, quoting reference DE/12/6546.
Wiltshire Police are appealing for information regarding a burglary which took place in Swindon.
During the evening of Saturday 19th May, a man gained entry to a property in Beckhampton Street.
He is described as white, aged in his late twenties, and 6ft tall.
He had short dark hair and was wearing a white polo shirt and dark trousers.
Anyone with information regarding the identity of the man is asked to contact PC Adam Leakey of the Swindon Priority Crime Team on 101 or anonymously via Crimestoppers on 0845 555 111.