Plymouth Argyle beat Southend in League Two, while Torquay United were the region's only other winners.
Former Yeovil Town striker Paddy Madden returned to haunt his old club with a late equalising goal. Exeter City and Torquay also drew.
Plymouth Argyle were victorious in the first Devon derby of the season. Yeovil Town lost at Gillingham, while Torquay drew with Southport.
Plymouth Argyle have been knocked out of the League Cup on penalties, as all our sides crashed out.
After going two goals down to Leyton Orient, Reuben Reid scored twice to take the game into extra time. After falling behind again, Carl McHugh made it 3-3. But the League One side won 6-5 on sudden death spot-kicks.
Elsewhere, Exeter City lost 2-0 at home to Championship side Bournemouth.
Yeovil Town lost 2-1 at home to League One rivals Gillingham.
And Torquay United have won their first game in the Conference. They beat Welling 3-0 thanks to goals from Ryan Bowman, Courtney Cameron and Toby Ajala.
In football, it's the first round of the Capital One Cup tonight. Exeter City host Championship side Bournemouth, while Plymouth Argyle entertain Leyton Orient at Home Park. Yeovil Town play Gillingham.
The football season gets underway tomorrow for all of our professional sides - and today we look at the hopes for Exeter City.
It's been a turbulent summer at St James Park. The club has run out of cash, and been banned from signing any new players.
Today the Chief Executive resigned - following other senior management out of the door - as the season begins in crisis.
Seth Conway reports:
For fans of Torquay United, last season was a painful one - with relegation from League Two taking them into the conference.
Today - in the latest of our previews of all our main teams - we look at their prospects for the new season.
Here's Seth Conway:
For United fans last season was a painful one - with relegation from League 2 taking them into the conference.
But as pre-seasons go there's plenty to be optimistic about at Torquay. Striker Ryan Bowman sent United on their way to victory in Saturday's friendly at Exeter City as what is now a new and youthful Gulls side will be very competitive in the Football Conference.
In the latest of our previews of all our main teams, we look at their prospects for the new season. Here is our full interview with manager Chris Hargreaves.
It's three days and counting to the start of the new football season. As part of our series of profiles of all our main teams - today we look at the prospects for Yeovil Town.
This time a year ago the team was buoyant after promotion to the Championship, but relegation followed, and Town are now back in League One.
Tim Walsh reports:
The new football season begins on Saturday and all this week we're looking at how our teams are shaping up for kick off.
Plymouth Argyle manager John Sheridan has been busy in the transfer market as he hopes to improve on last season's 10th place finish.
Jacquie Bird reports:
Exeter City are due to land in Brazil later this morning ahead of their three game tour of the country. They play their first match on Sunday. The trip marks the centenary of the club's South American Tour of 1914.